The effect of experimental anemia of radioactive
Co60-Chlorophyllin, its distribution in the body and the therapeutic
effect of Co-Chlorophyllin on anemia. Tamura K.
1959. Keio J.Med. (Japan). Vol.36 (
View abstract)
When 5 mg of non-radioactive Co-chlorophyllin was injected before
irradiation, inhibition of the decrease in the blood cell counts and
promotion of recovery were more marked than in controls receiving no
injections. Co-chlorophyllin increased the leucocyte count and
hemoglobin content in rats and directly or indirectly stimulated
hematopoiesis (blood formation). The radioactive Co-chlorophyllin was
accumulated and was stored for a long time mostly in
the reticulo-endothelial system (RES) such as the liver, spleen, and
bone marrow. Co-chlorophyllin was injected intravenously in 200 cases
of malignant tumor treated with irradiation. Compared with those in 70
cases treated with radiation alone, the increase in the hemoglobin
content, erythrocyte, and leucocyte counts was more marked, and the
inhibition of decrease in the blood cell counts was also stronger than
in the uninjected group.
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