The role of iron chelation activity of wheat grass juice in blood transfusion requirement of intermediate thalassaemia.
Mukhopadhyay. S., Mukhopadhyay. A., Gupta. P., Kar. M., Ghosh. A. 2007 Am. Soc. Hematol. Ann.
The authors noted there was no satisfactory explanation for reduced blood transfusion requirements in thalassemia major patients treated with fresh wheatgrass juice.
(Marwaha et al) 30mls of fresh wheatgrass juice extracted from 6 week old wheatgrass plants was given daily to 200 thalassemia intermedia patients over 6 months. They included E-beta thalassemia (160 patients), E-thalassemia, (30 patients) and 10 patients with Sickle thalassemia. Significant iron chelating activity comparable with a standard pharmaceutical chelator, desferrioxamine, was observed. Mean hemoglobin levels increased from 6.2gm% to 7.8gm%. Serum ferritin levels decreased significantly and the 24 patients requiring incremental blood transfusion enjoyed an increased interval between transfusions. The authors concluded that wheatgrass juice is an effective alternative to blood transfusion in thalassemia intermedia patients and its use should be encouraged.
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