Chlorophyll: an experimental study of its water-soluble derivatives.
I. remarks upon the history, chemistry, toxicity and antibacterial
poperties of water-soluble chlorophyll derivatives as therapeutic
agents. Smith L. 1944. Am. J. Med. Sci. 207:647-654
Reviews the chemistry of chlorophyll, including the structural formula
(C 55H 72O 5N 4Mg) and provides a list of references. Chlorophyll can
be obtained from leaves by extraction with acetone. Chlorophyll is
similar to hemoglobin, but in hemoglobin iron is substituted for
magnesium, globin is substituted for the phytyl radical, and at Carbon
4 ther is an allyl instead of en ethyl residue. Water-soluble
chlorophyll is more preferable in clinical use than the oil-soluble
form. This study examined the toxic effects of chlorophyll on rabbits
with the solution being administered by mouth, intravenously,
intraperitoneally and subcutaneously. There was a total absence of
toxic effects. Chlorophyll is thought to produce an unfavourable
environment for bacterial growth resulting in a bacteriostatic effect.
It is important in the treatment of infected surface wounds and appears
to contribute to rapid tissue repair.
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